Human Intrinsic Factor Expression for Bioavailable Vitamin B12 Enrichment in Microalgae
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چکیده
منابع مشابه
Human Intrinsic Factor Expression for Bioavailable Vitamin B12 Enrichment in Microalgae
Dietary supplements and functional foods are becoming increasingly popular complements to regular diets. A recurring ingredient is the essential cofactor vitamin B12 (B12). Microalgae are making their way into the dietary supplement and functional food market but do not produce B12, and their B12 content is very variable. In this study, the suitability of using the human B12-binding protein int...
متن کاملThe effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency.
We report on the use of recombinant human intrinsic factor (rhIF) in a new vitamin B12 absorption test. Holotranscobalamin (holoTC) was measured before and 24 hours after intake of three 9-mg doses of vitamin B12 (B12) and again 24 hours after intake of the same dose of B12 together with rhIF (rhIF-B12). Nine patients with evident vitamin B12 deficiency had a significantly higher increase in ho...
متن کاملTransplacentally acquired antibody to intrinsic factor with vitamin B12 deficiency.
ANTIBODY TO INTRINSIC FACTOR is found in the blood of about 60% of patients with pernicious anemia, and when present is considered pathognomonic of pernicious anemia, whether incipient or overt.”2 It is not clear whether the antibody has any etiological role in the disease or whether it is perhaps secondary to gastric injury, in which materials derived from gastric parietal cells are released i...
متن کاملA simple assay of intrinsic factor-vitamin B12 complex employing the binding intrinsic factor antibody.
The reaction between binding intrinsic factor antibody and intrinsic factor-vitamin B(12) complex has been studied. Initially in the zone of antibody excess, the relationship between the amount of antigen present and the amount of antigen-antibody complex adsorbed onto zirconium phosphate gel was linear. With increasing amounts of antigen, the curve departed from linearity and reached a plateau...
متن کاملHematologic responses and concentration of vitamin B12 in serum and urine following oral administration of vitamin B12 without intrinsic factor.
By G. I. M. Ross, M.B., Cri.B. D.C.P.,* D. L. MOLLIN, B.SC., M.B., Cnl.B., E. V. Cox, B.Sc., M.B., B.S., AND C. C. TJNGLEY, M.D., M.R.C.P.* T LIE ABSORPTIOX from the imnt.cstinal tract of small doses of n-itaminn B,2 is impaired inn paticnnts with pernicious anemia. Small doses such as 5 g. gin-cnn daily by mouth produce little or rio hematologic respomise, unnless gin-cnn ssit.in a source of i...
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ژورنال
عنوان ژورنال: Biology
سال: 2018
ISSN: 2079-7737
DOI: 10.3390/biology7010019